全球顶尖双轨菌株库
每一株都可溯源、可验证

全球合作进口菌株库

动物双歧杆菌乳亚种B420 动物双歧杆菌乳亚种 HN019 嗜酸乳杆菌 NCFM 鼠李糖乳酪杆菌LGG 鼠李糖乳酪杆菌 HN001 嗜酸乳杆菌 La-14

鼠李糖乳酪杆菌 HN001

菌株拉丁名
Lacticaseibacillus rhamnosus HN001
菌株形态
活性益生菌
原料来源
奶酪
临床功效
私密健康、免疫健康、消化健康、大脑健康、代谢健康
临床研究数量
92项
临床人体受试者
16113人
推荐适用人群
产后皮肤敏感（湿疹/皮炎）和情绪健康支持人群；改善与年龄相关的皮肤屏障衰退和炎症性衰老人群。
禁忌适用人群
严重免疫功能低下者或急性全身性感染患者。
健康预期功效

改善皮肤屏障功能，减少过敏性皮肤突发症状；

支持产后心理健康（降低焦虑/抑郁评分）。

作用机制

HN001菌株 → 免疫Th1/Th2平衡：调节免疫应答，减少过敏致敏 → 肠-皮轴：降低引发皮肤发红/瘙痒的全身性炎症 → 神经-代谢信号传导：调节与情绪调控相关的细胞因子通路 → 结果：肤质更清透，情绪弹性提升

证据等级
证据类型 人类随机对照试验数据分析观察性研究动物实验 / 体外实验
可用性
局限性与注意事项
  • 聚焦：主要针对女性/免疫/皮肤/情绪。
  • 剂量：大多数临床成功案例采用每日60亿CFU。
  • 起效周期：情绪和皮肤方面的益处通常需要长期使用（2-6个月）。

Effect of Lactobacillus rhamnosus HN001 in Pregnancy on Postpartum Symptoms of Depression and Anxiety: A Randomised Double-blind Placebo-controlled Trial

University of Auckland

Effects of Lactobacillus rhamnosus HN001 in early life on the cumulative prevalence of allergic disease to 11 years

University of Otago

Probiotics for the Prevention of Gestational Diabetes Mellitus in Overweight and Obese Women: Findings From the SPRING Double-Blind Randomized Controlled Trial

University of Queensland

Lactobacilli vaginal colonisation after oral consumption of Respecta® complex (HN001/LA-14)

University of Milan

Effects of Lactobacillus rhamnosus HN001 in early life on the cumulative prevalence of allergic disease to 11 years

University of Wellington

A Healthy Vaginal Microbiota Remains Stable during Oral Probiotic Supplementation: A Randomised Controlled Trial

University of Turku

Systemic immunity-enhancing effects in healthy subjects following dietary consumption of the lactic acid bacterium Lactobacillus rhamnosus HN001

Massey University

Early pregnancy probiotic supplementation with Lactobacillus rhamnosus HN001 may reduce the prevalence of gestational diabetes mellitus: a randomised controlled trial

University of Auckland

Efficacy of probiotics and lactoferrin in women with Recurrent Vulvovaginal Candidiasis

University of Otago

Microencapsulation of Lactobacillus rhamnosus HN001 by spray drying and its evaluation under gastrointestinal and storage conditions

Federal University of Uberlândia