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Bifidobacterium animalis subsp. lactis B420 Bifidobacterium animalis subsp. lactis HN019 Lactobacillus acidophilus NCFM Lacticaseibacillus rhamnosus GG Lacticaseibacillus rhamnosus HN001 Lactobacillus acidophilus La-14

Bifidobacterium animalis subsp. lactis B420

Latin Name
Bifidobacterium animalis subsp. lactis B420
Form
Live Probiotic Cult
Source
Dairy
Clinically Studied Benefits
Metabolic Health、Immune Health、Digestive Health、Brain Health
Clinical Studies
30
Clinical Human Participants
6248
Recommended Population
Adults seeking weight management or metabolic health improvement.
Contraindicated Population
Immunocompromised individuals, patients with acute pancreatitis, or those with post-surgery open wounds.
Target Health Outcomes

Waist Circumference Shrinkage: Clinically proven to reduce waist size, helping restore pre-pregnancy body silhouette.<wbr/>

Combating Visceral Adiposity: Directly addresses the increase in deep belly fat (visceral fat) associated with hormonal aging.<wbr/>

Prevention of "Menopausal Middle": Helps mitigate the rapid expansion of waist circumference and improves postprandial glucose tolerance.

Mechanism of Action

B420 →Strengthens Gut Barrier (Tight Junctions) → <wbr/> Lowers LPS (Systemic Endotoxins) → <wbr/> Boosts GLP-1/PYY (Satiety) → <wbr/> Result: Reduced Visceral Adipose Tissue (VAT).

Evidence Grade
Evidence Type Human RCTMeta-analysisObservationalAnimal/In-vitro
Availability
Known Limitation & Uncertainties
  • Population: Evidence focused on overweight/obese cohorts.<wbr/>
  • Duration: Significant results typically require 3~6 months of intake.<wbr/>
  • Synergy: Enhanced effects when combined with prebiotic fibers.

1、Randomized controlled trial demonstrates response to a probiotic intervention for metabolic syndrome that may correspond to diet

DOI: 10.1080/19490976.2023.2178794 Stanford University

2、Probiotic With or Without Fiber Controls Body Fat Mass, Associated With Serum Zonulin, in Overweight and Obese Adults—Randomized Controlled Trial

DOI: 10.1016/j.ebiom.2016.10.036 DuPont Nutrition & Health

3、Probiotic or synbiotic alters the gut microbiota and metabolism in a randomised controlled trial of weight management in overweight adults

DOI: 10.3920/BM2018.0028 DuPont Nutrition & Health

4、Polydextrose with and without Bifidobacterium animalis ssp. lactis 420 drives the prevalence of Akkermansia and improves liver health in a multi-compartmental obesogenic mice study

DOI: 10.1371/journal.pone.0260765 IFF Health & Biosciences

5、The efficacy of probiotics and/or n-3 long-chain polyunsaturated fatty acids intervention on maternal prenatal and postnatal depressive and anxiety symptoms among overweight and obese women

DOI: 10.1007/s00394-022-02852-9 University of Turku

6、Effects of Bifidobacterium animalis ssp. lactis 420 on gastrointestinal inflammation induced by a nonsteroidal anti-inflammatory drug: A randomized, placebo-controlled, double-blind clinical trial

DOI: 10.1111/bcp.14880 IFF Health & Biosciences

7、Iodine status in pregnant women and infants in Finland

DOI: 10.1007/s00394-022-02852-9 University of Turku

8、The effect of probiotics on faecal microbiota and genotoxtic activity of faecal water in patients with atopic dermatitis: a randomized,_placebo-controlled study

DOI：10.1016/j.clnu.2011.08.012 Friedrich Schiller University Jena

9、Bifidobacterium lactis Fermented Milk Was Not Effective for Helicobacter pylori Eradication: A Prospective, Randomized, Double-Blind, Controlled Study

DOI：10.5281/zenodo.1099690 University of São Paulo (USP)

10、The immune system in healthy adults and patients with atopic dermatitis seems to be affected differently by a probiotic intervention

DOI：10.1111/j.1365-2222.2007.02876.x Friedrich Schiller University Jena