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Global Strain Library

Bifidobacterium animalis subsp. lactis B420 Bifidobacterium animalis subsp. lactis HN019 Lactobacillus acidophilus NCFM Lacticaseibacillus rhamnosus GG Lacticaseibacillus rhamnosus HN001 Lactobacillus acidophilus La-14

Lacticaseibacillus rhamnosus HN001

Latin Name
Lacticaseibacillus rhamnosus GG
Form
Live Probiotic Culture
Source
Cheese
Clinically Studied Benefits
Intimate Health、Immune Health、Digestive Health、Brain Health、Metabolic Health
Clinical Studies
92
Clinical Human Participants
16113
Recommended Population
Postpartum skin sensitivity (eczema/dermatitis) and emotional well-being support. Addressing age-related skin barrier decline and "inflammaging."
Contraindicated Population
Severely immunocompromised individuals or those with acute systemic infections.
Target Health Outcomes

Improvement in Skin Barrier Function and reduction in allergic skin flare-ups.

Support for Postpartum Mental Wellness (reduction in anxiety/depression scores).

Mechanism of Action

HN001 Strain →<wbr/> Immune Th1/Th2 Balance: Shifts immune response to reduce allergic sensitization →<wbr/> Gut-Skin Axis: Lowers systemic inflammation that triggers skin redness/itching →<wbr/> Neuro-Metabolic Signaling: Modulates cytokine pathways linked to mood regulation →<wbr/> Result: Clearer Skin Texture and improved Emotional Resilience

Evidence Grade
Evidence Type Human RCTMeta-analysisObservationalAnimal/In-vitro
Availability
Known Limitation & Uncertainties
  • Focus: Primarily an Female/Immune/Skin/Mood.
  • Dosage: Most clinical success seen at 6 billion CFU/day.
  • Consistency: Benefits for mood and skin often require long-term use (2–6 months).

1、Effect of Lactobacillus rhamnosus HN001 in Pregnancy on Postpartum Symptoms of Depression and Anxiety: A Randomised Double-blind Placebo-controlled Trial

DOI: 10.1016/j.ebiom.2017.09.013 University of Auckland

2、Effects of Lactobacillus rhamnosus HN001 in early life on the cumulative prevalence of allergic disease to 11 years

DOI: 10.1111/pai.12982 University of Otago

3、Probiotics for the Prevention of Gestational Diabetes Mellitus in Overweight and Obese Women: Findings From the SPRING Double-Blind Randomized Controlled Trial

DOI: 10.1111/pai.12982 University of Queensland

4、Lactobacilli vaginal colonisation after oral consumption of Respecta® complex (HN001/LA-14)

DOI: 10.1007/s00404-015-3711-4 University of Milan

5、Effects of Lactobacillus rhamnosus HN001 in early life on the cumulative prevalence of allergic disease to 11 years

DOI: 10.1111/pai.12982 University of Wellington

6、A Healthy Vaginal Microbiota Remains Stable during Oral Probiotic Supplementation: A Randomised Controlled Trial

DOI: 10.3390/microorganisms11020499 University of Turku

7、Systemic immunity-enhancing effects in healthy subjects following dietary consumption of the lactic acid bacterium Lactobacillus rhamnosus HN001

DOI: 10.1080/07315724.2001.10719027 Massey University

8、Early pregnancy probiotic supplementation with Lactobacillus rhamnosus HN001 may reduce the prevalence of gestational diabetes mellitus: a randomised controlled trial

DOI: 10.1017/S0007114517000289 University of Auckland

9、Efficacy of probiotics and lactoferrin in women with Recurrent Vulvovaginal Candidiasis

DOI: 10.1111/myc.12883 University of Otago

10、Microencapsulation of Lactobacillus rhamnosus HN001 by spray drying and its evaluation under gastrointestinal and storage conditions

DOI：10.1016/j.lwt.2021.112485 Federal University of Uberlândia