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Global Strain Library

Bifidobacterium animalis subsp. lactis B420 Bifidobacterium animalis subsp. lactis HN019 Lactobacillus acidophilus NCFM Lacticaseibacillus rhamnosus GG Lacticaseibacillus rhamnosus HN001 Lactobacillus acidophilus La-14

Lacticaseibacillus rhamnosus GG

Latin Name
Lacticaseibacillus rhamnosus GG
Form
Live Probiotic Culture
Source
Healthy Human
Clinically Studied Benefits
Digestive Health、Immune Health、Metabolic Health、Oral Health、Pregnancy & Infants、Women's Health、Brain Health
Clinical Studies
168
Clinical Human Participants
11457
Recommended Population
Stress-induced digestive sensitivity and postpartum immune support.Gut-related skin sensitivity and general inflammatory balance.
Contraindicated Population
Immunocompromised individuals or patients with central venous catheters.
Target Health Outcomes

Improvement in Intestinal Permeability (reducing "Leaky Gut" symptoms).

Reduction in Gastrointestinal Sensitivity and support for Immune Defense.

Mechanism of Action

LGG Strain →<wbr/> Physical Attachment: High adhesion to intestinal mucus via pili →<wbr/> Competitive Exclusion: Blocks pathogens from colonizing the gut wall →<wbr/> Barrier Reinforcement: Stimulates mucin production and tight junction integrity →<wbr/> Result: Enhanced Immune Resilience and reduced gut inflammation.

Evidence Grade
Evidence Type Human RCTMeta-analysisObservationalAnimal/In-vitro
Availability
Known Limitation & Uncertainties
  • Focus: Primarily targets Digestive/Immune health.
  • Stability: Highly dependent on manufacturing quality to maintain "pili" integrity for adhesion.
  • Duration: Acute digestive issues show results in days; immune modulation requires 4–8 weeks.

Lactobacillus rhamnosus GG versus Placebo for Acute Gastroenteritis in Children

Harvard Medical School

An Open-label, Multicenter Study to Assess the Efficacy and Safety of a Novel Probiotic Blend in Patients with Functional Gastrointestinal Symptoms

Mayo Clinic

Formula selection for management of children with cow's milk allergy influences the rate of acquisition of tolerance: a prospective multicenter study

Johns Hopkins University

Probiotics to reduce antibiotic administration in care home residents aged 65 years and older: the PRINCESS RCT

University of Oxford

Dietary Treatment with Extensively Hydrolyzed Casein Formula Containing the Probiotic Lactobacillus rhamnosus GG Prevents the Occurrence of Functional Gastrointestinal Disorders in Children with Cow's Milk Allergy

University of Naples Federico

A randomized, double-blind trial of Lactobacillus GG versus placebo in addition to standard maintenance therapy for children with Crohn's disease

Massachusetts General Hospital

Successful treatment of relapsing Clostridium difficile colitis with Lactobacillus GG

Tufts University

Effect of Lactobacillus GG on intestinal integrity in Malawian children at risk of tropical enteropathy

Washington University in St. Louis

Probiotics to minimize the disruption of faecal microbiota in healthy subjects undergoing antibiotic therapy

North Carolina State University

Transcriptomic Profile of Whole Blood Cells from Elderly Subjects Fed Probiotic Bacteria Lactobacillus rhamnosus GG ATCC 53103 (LGG) in a Phase I Open Label Study

University of Maryland