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Bifidobacterium animalis subsp. lactis B420 Bifidobacterium animalis subsp. lactis HN019 Lactobacillus acidophilus NCFM Lacticaseibacillus rhamnosus GG Lacticaseibacillus rhamnosus HN001 Lactobacillus acidophilus La-14

Lactobacillus acidophilus La-14

Latin Name
Lactobacillus acidophilus La-14
Form
Live Probiotic Culture
Source
Healthy Human
Clinically Studied Benefits
Intimate Health、Immune Health、Digestive Health、Brain Health
Clinical Studies
29
Clinical Human Participants
2037
Recommended Population
Managing vaginal dryness and pH imbalance caused by estrogen decline.<wbr/>
Contraindicated Population
Severely immunocompromised patients or individuals with acute vaginal trauma.
Target Health Outcomes

Restoration of Vaginal Microbiota Balance (increasing Lactobacillus dominance).

Reduction in the recurrence of Vaginal and Urinary Tract Discomfort.

Mechanism of Action

LA-14 Strain →<wbr/> Oral-to-Vaginal Migration: Survives digestion and migrates to the vaginal tract →<wbr/> Lactic Acid Production: Lowers local pH to inhibit harmful pathogens →<wbr/> Bacteriocin Secretion: Produces natural antimicrobial substances (acidophilin) →<wbr/> Result: Maintains a Healthy Acidic Environment and prevents dysbiosis.

Evidence Grade
Evidence Type Human RCTMeta-analysisObservationalAnimal/In-vitro
Availability
Known Limitation & Uncertainties
  • Specificity: Primarily targets Urogenital Health.
  • Timing: Best used as a long-term preventive measure rather than an acute treatment for active infections.
  • Synergy: Highly effective when combined with HN001 for comprehensive female care.

1、Randomized controlled trial demonstrates response to a probiotic intervention for metabolic syndrome that may correspond to diet

DOI: 10.1080/19490976.2023.2178794 Stanford University

2、A Healthy Vaginal Microbiota Remains Stable during Oral Probpiotic Supplementation: A Randomised Controlled Trial

DOI：10.3390/microorganisms11020499 University of Helsinki

3、A New Therapy for Uncomplicated Vulvovaginal Candidiasis and Its Impact on Vaginal Flora

DOI：10.3390/healthcare9111555 University of Trieste

4、Randomized clinical trial in women with Recurrent Vulvovaginal Candidiasis: Efficacy of probiotics and lactoferrin as maintenance treatment

DOI：10.1111/myc.12883 University of Trieste

5、Efficacy of vaginal preparation containing Lactobacillus acidophilus, lactic acid and deodorized garlic extract in treatment and prevention of symptomatic bacterial vaginitis: result from a single-arm pilot study

DOI:10.14660/2385-0868-82 University

6、Evidence-based mixture containing Lactobacillusstrains and lactoferrin to prevent recurrent bacterial vaginosis: a double blind, placebo controlled, randomised clinical trial

DOI: 10.3920/BM2018.0075 University of Trieste

7、Study on the effects of an oral lactobacilli and lactoferrin complex in women with intermediate vaginal microbiota

DOI: 10.1007/s00404-018-4771-z University of Trieste

8、Lactobacilli vaginal colonisation after oral consumption of Resspecta® complex: a randomized controlled pilot study

DOI: 10.1007/s00404-015-3711-4 University of Milam

9、The Effect of Synbiotic Supplementation on Uremic Toxins. Oxidative Stress, and Inflammation in Hemodialysis Patients-Results of an Uncontrolled Prospective Single-Arm Study

DOI: 10.3390/medicina59081383 Medical University of Plovdiv

10、Mixture of probiotics reduces inflammatory biomarkers and inmproves the oxidative/nitrosative profile in people with rheumatoid arthritis

DOI: 10.1016/j.nut.2021.111282 State University of Londrina

11、Severe allergic rhinitis, perennial sinusitis and antthistamine dependence resolved with naturopathic treatment: A case study and short literature review

Endeavour College of Natural Health